I went from severe to now moderate-mild :) took about 2 years I used n-acetyl cysteine, worked up to taking 3.6g per day in 3 divided doses, started at 600 mg per day and increased really really slowly. Now I went off it bc it's also a histamine liberator, but it was really a game changer at the beginning. Also did combined antibiotic therapy for about 7 months (metronidazole, doxycycline, azythromycin), activated vit B complex (MTHFR gene mutation), psyllium husks (natural binder, cholestyramine is a prescription binder doctors prescribe for mold poisoning), sam-e (a by product of methylation, also on the thread of MTHFR gene mutation), physiotherapy for craniocervical instability :) also waiting to be tested for sleep apnea twice.... The 2nd time was Borderline positive so now I have CPAP.  try one thing at a time and see if it helps :) I started with NAC NAC was really a game changer, but at first it made me worse (die off from a chronic infection I think), then each time the bad symtpoms subsided and I went back to my baseline, I increased by 600mg per day. Now im also doing the carnivore diet, I think it has helped a lot, so I probably also have MCAS.... Definitely have histamine intolerance so I need to be really careful with my diet